博士 2003-2006 57365线路检测中心官网 细胞生物学
硕士 2000-2003 山东农业大学 兽医微生物与免疫
本科 1996-2000 山东农业大学 畜牧
工作经历
2006.7-2008.9 57365线路检测中心官网 讲师
2008.9-2017.9 副教授
2011.7-2012.8 东田纳西州立大学 访问学者
2017.9-至今 教授
科研方向
1.心血管细胞分化，凋亡及自噬的分子机制研究。
2.鞘氨醇磷酸胆碱的生物学功能研究。
主持课题
1. 2017.1-2020. 12. 鞘氨醇磷酸胆碱促进缺氧心肌线粒体自噬的分子机制研究. （31671180），直接费用61.00万
2. 2014.1-2017.12. MiR-155/β-arrestin 2/GSK3β通路在Sca-1+心脏干细胞向心肌分化中的功能研究. 国家自然科学基金面上项目（31371158），81 万
3. 2017.1-2020. 12. 鞘氨醇磷酸胆碱在心肌梗死诊治中的应用及相关机制研究，省科技攻关/2016GSF201035，10.00万；
4. 2010.12-2013.12. 鞘氨醇磷酸胆碱诱导血管内皮细胞自噬的分子机制研究。国家自然科学基金面上项目（31070999）33万
5. 2010.12-2013.12. 基于化学小分子的血管形成机理研究。国家博后特别资助（201003638）10万
7. 2015.10-2016.10腐殖酸痛风抑制剂的研制与开发。山东创新腐殖酸科技股份有限公司，12万。
近五年代表性论文（*联系作者）
1.Ge D, Gao J, Han L, Li Y, Liu HH, Yang WC, Chang F, Liu J, Yu M, Zhao J*. Novel effects of sphingosylphosphorylcholine on the apoptosis of breast cancer via autophagy/AKT/p38 and JNK signaling. J Cell Physiol. 2019 Jul;234(7):11451-11462.
2.Ge D, Yue HW, Liu HH, Zhao J*. Emerging roles of sphingosylphosphorylcholine in modulating cardiovascular functions and diseases. Acta Pharmacol Sin. 2018 Dec;39(12):1830-1836.
3.Liu H, Liu P, Shi X, Yin D, Zhao J*. NR4A2 protects cardiomyocytes against myocardial infarction injury by promoting autophagy. Cell Death Discov. 2018 Feb 15;4:27.
4.Liu PP, Liu HH, Sun SH, Shi XX, Yang WC, Su GH, Zhao J*. Aspirin alleviates cardiac fibrosis in mice by inhibiting autophagy. Acta Pharmacol Sin. 2017 Apr;38(4):488-497.
5.Xingxing Shi, Wenjing Li, Honghong Liu, Deling Yin and Jing Zhao. The ROS/NF-κB/NR4A2 pathway is involved in H2O2 induced apoptosis of resident cardiac stem cells via autophagy
Oncotarget, 2017; 8:77634-77648.
6.Liu J, Fu H, Chang F, Wang J, Zhang S, Caudle Y, Zhao J*, Yin D*. Sodium orthovanadate suppresses palmitate-induced cardiomyocyte apoptosis by regulation of the JAK2/STAT3 signaling pathway. Apoptosis. 2016 May;21(5):546-57.
7.Chang F, Liu J, Fu H, Wang J, Li F, Yue H, Li W, Zhao J*, Yin D*. GSK-3β promotes PA-induced apoptosis through changing β-arrestin 2 nucleus location in H9c2 cardiomyocytes. Apoptosis. 2016 Sep;21(9):1045-55.
8.Liu J, Fu H, Chang F, Wang J, Zhang S, Caudle Y, Zhao J*, Yin D*. Sodium orthovanadate suppresses palmitate-induced cardiomyocyte apoptosis by regulation of the JAK2/STAT3 signaling pathway. Apoptosis. 2016 Sep;21(9):1045-55.
9.Wenjing Li, Honghong Liu, Pingping Liu, Deling Yin, Shangli Zhang, Jing Zhao*. Sphingosylphosphorylcholine promotes the differentiation of resident Sca-1 positive cardiac stem cells to cardiomyocytes through lipid raft/JNK/STAT3 and β-catenin signaling pathways. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. 2016,1579-1588.
10.Yue HW, Liu J, Liu PP, Li WJ, Chang F, Miao JY, Zhao J*. Sphingosylphosphorylcholine protects cardiomyocytes against ischemic apoptosis via lipid raft/PTEN/Akt1/mTOR mediated autophagy. Biochim Biophys Acta. 2015 Sep;1851(9):1186-93.
11.Ge D, Jing Q, Zhao W, Yue H, Su L, Zhang S, Zhao J*. Finding ATF4/p75NTR/IL-8 signal pathway in endothelial-mesenchymal transition by safrole oxide. PLoS One. 2014 Apr 7;9(4):e92661.
