黄启来  教授

qlhuang@sdu.edu.cn

教育背景

博士 2000.9-2005.11 南京大学 生化与分子生物学

本科 1996.9-2000.7 烟台大学 生物化学

工作经历

2014.11- 至今 57365线路检测中心官网 教授

2012.03-2013.12 芬兰奥卢大学 高级研究员

2009.09-2011.06 澳门科技大学 助理教授

2006.09-2009.09 南京大学 博士后

科研方向

1. 癌症易感遗传变异的分子机制

2. 肿瘤的基因调控

3. 恶性肿瘤生长和转移的机制

4. 基因组编辑技术

执教课程

1.肿瘤生物学

2.医学免疫学

研究成果

1.Naixia Ren, Qingqing Liu, Lingjie Yan and Qilai Huang*. 2021, Parallel Reporter Assays Identify Altered Regulatory Role of rs684232 in Leading to Prostate Cancer Predisposition. Int. J. Mol. Sci. 22, 8792.

2.Naixia Ren, Yingying Li, Yulong Xiong, Panfeng Li, Yutian Ren and Qilai Huang*. 2021, Functional Screenings Identify Regulatory Variants Associated with Breast Cancer Susceptibility. Curr. Issues Mol. Biol. 43, 1756–1777.

3.Shumin Ma, Naixia Ren and Qilai Huang*. 2021, rs10514231 Leads to Breast Cancer Predisposition by Altering ATP6AP1L Gene Expression. Cancers. 13, 3752.

4.Bo Li, Naixia Ren, Lele Yang, Junhao Liu, Qilai Huang*. 2019, A qPCR method for genome editing efficiency determination and single-cell clone screening in human cells. Scientific Reports. 9:18877.

5.Bo Li, Qilai Huang*, Gong-Hong Wei*. 2019, The Role of HOX Transcription Factors in Cancer Predisposition and Progression. Cancers. 11, 528. doi:10.3390/cancers11040528.

6.Qilai Huang#, Thomas Whitington#, Ping Gao, Johan F. Lindberg, Yuehong Yang, Jielin Sun, Marja-Riitta Väisänen, Robert Szulkin, Matti Annala, Jian Yan, Lars A. Egevad, Kai Zhang, Ruizhu Lin, Arttu Jolma, Matti Nykter, Aki Manninen, Fredrik Wiklund, Markku H. Vaarala, Tapio Visakorpi, Jianfeng Xu, Jussi Taipale & Gong-Hong Wei. 2014, A prostate cancer susceptibility allele at 6q22 increases RFX6 expression by modulating HOXB13 chromatin binding. Nature Genetics. 46(2): 126-135.

7.Wenjing Zhang, Yan Lan, Qilai Huang*, Zichun Hua*. 2013, Galangin induces B16F10 melanoma cell apoptosis via mitochondrial pathway and sustained activation of p38 MAPK. Cytotechnology. 65(3):447-455.

8.Wenjing Zhang, Bo Tang, Qilai Huang*, Zichun Hua*. 2013, Galangin inhibits tumor growth and metastasis of B16F10 melanoma. J Cell Biochem. 114(1):152-161.

9.Qilai Huang, Chenguang Gong, Jiahuang Li, Zhu Zhuo, Yuan Chen, Jin Wang*, Zichun Hua*. 2012, Distance and helical phase dependence of synergistic transcription activation in cis-regulatory module. PLoS ONE 7(1): e31198. doi:10.1371/journal.pone.0031198.

10.Li Shiying¹, Huang Qilai¹, Wang Lu, Lan Yan, Zhang Xiangyu, Yang Bingya, Du Pan, Hua Zichun. 2010, A convenient spectrometric assay system for intracellular quantitative measurement of DNA glycosylase activity. Acta Biochim Biophys Sin (Shanghai). 42(6):381-387.

11.Qi-Lai Huang, Cheng Chen, Yun-Zi Chen, Chen-Guang Gong, Lin Cao, Jin Wang, Zi-Chun Hua. 2006. Application to Immunoassays of the Fusion Protein between Protein ZZ and Enhanced Green Fluorescent Protein. J. Immunol. Methods. 309:130-138.

12.Qi-Lai Huang, Cheng Chen, Yun-Zi Chen, Chen-Guang Gong, Jin Wang and Zi-Chun Hua. 2006. Fusion protein between protein ZZ and red fluorescent protein DsRed and its application to immunoassays. Biotechnol. Appl. Biochem. 43(2), 121-127.