鲁庆：研究员，博士、硕士生导师，57365线路检测中心官网齐鲁青年学者

邮箱：qing.lu@sdu.edu.cn

教育背景：

学士 2008.09-2012.06 北京科技大学 生物技术

硕士 2012.09-2015.06 57365线路检测中心官网 生物工程

博士 2015.09-2021.05 比利时根特大学 生物技术与生物化学

工作经历：

博士后 2021.06-2022.06 比利时根特大学

研究方向：

一、解析大豆固氮、高产分子机制和遗传网络。主要利用大豆突变体及自然群体材料，结合遗传学、分子生物学、基因组学、细胞生物学等手段，定位及克隆大豆固氮和高产相关基因，鉴定基因功能、解析其调控固氮的产量的分子机制和遗传网络，为分子育种提供理论基础。

二、开发可提高大豆固氮能力及产量的新型植物生长调节剂。依据大豆固氮、高产等分子调控网络，建立高通量筛选可提高大豆固氮能力、产量等化学小分子的方法，并解析相关小分子的作用机制，利用相关化学小分子工具研究大豆高产、抗逆分子机制，并推进其在实际生产中的应用。

与向凤宁教授合作常年招收博士后研究人员，欢迎对相关研究方向感兴趣的硕士、博士报考。

研究成果：

1. Lu Q, Houbaert A, Ma Q, Huang J, Sterck L, Zhang C, Benjamins R, Coppens F, Van Breusegemn F, Russinova E. (2022) Adenosine monophosphate deaminase modulates BIN2 activity through hydrogen peroxide-induced oligomerization. Plant Cell, 34, 3844–3859.

2. Lu Q, Zhang Y, Hellner J, Giannini C, Xu X, Pauwels J, Ma Q, Dejonghe W, Han H, Van de Cotte B, Impens F, Gevaert K, De Smet I, Friml J, Molina DM, Russinova E. (2022) Proteome-wide cellular thermal shift assay reveals unexpected cross-talk between brassinosteroid and auxin signaling. Proc Natl Acad Sci 119(11): e2118220119.

3. Lu Q, Russinova E. (2022) Cellular thermal shift assay for the detection of small molecule-target interactions in Arabidopsis cells. Chapter 3 in Cell-wide Identification of Metabolite-protein Interactions, Methods in Molecular Biology.

4. Dai X, Lu Q, Wang J, Wang L, Xiang F, Liu Z. (2021). MiR160 and its target genes ARF10, ARF16 and ARF17 modulate hypocotyl elongation in a light, BRZ, or PAC-dependent manner in Arabidopsis: miR160 promotes hypocotyl elongation. Plant Sci, 303, 110686.

5. Dejonghe W, Sharma I, Denoo B, De Munck S, Lu Q, Mishev K, Bulut H, Mylle E, De Rycke R, Vasileva M, Savatin DV, Nerinckx W, Staes A, Drozdzecki A, Audenaert D, Yperman K, Madder A, Friml J, Van Damme D, Gevaert K, Haucke V, Savvides SN, Winne J., Russinova E. (2019). Disruption of endocytosis through chemical inhibition of clathrin heavy chain function. Nat Chem Biol, 15, 641-649.

6. Mishev K#, Lu Q#, Denoo B, Peurois F, Dejonghe W, Hullaert J, Rycke RD, Boeren S, Bretou M, Munck SD, Sharma I, Goodman K, Kalinowska K, Storme V, Nguyen LSL, Drozdzecki A, Martins S, Nerinckx W, Audenaert D, Vert G, Madder A, Otegui MS, Isono E, Savvides SN, Annaert W, Vries SD, Cherfils J, Winne J, Russinova E. (2018). Nonselective chemical inhibition of Sec7 domain-containing ARF GTPase exchange factors. Plant Cell, 30, 2573-2593.

7. Kania U, Nodzyński T, Lu Q, Hicks GR, Nerinckx W, Mishev K, Peurois F, Cherfils J, Rycke RD, Grones P, Robert S, Russinova E, Friml J. (2018). The inhibitor endosidin 4 targets SEC7 domain-type ARF GTPase exchange factors and interferes with subcellular trafficking in eukaryotes. Plant Cell, 30, 2553-2572.

8. Ortiz-Morea, FA, Savatin DV, Dejonghe W, Kumar R, Luo Y, Adamowski M, Van den Begin J, Dressano K, Pereira de Oliveira G, Zhao X, Lu Q, Madder A, Friml J, Scherer de Moura D, Russinova E. (2016). Danger-associated peptide signaling in Arabidopsis requires clathrin. Proc Natl Acad Sci 113(39): 11028–11033.

9. Liu Z, Li J, Wang L, Li Q, Lu Q, Yu Y, Li S, Bai M, Hu Y, Xiang F. (2016). Repression of callus initiation by the miRNA-directed interaction of auxin–cytokinin in Arabidopsis thaliana. Plant J 87(4):391–402.

10. Kvasnica, M, J Oklestkova, V Bazgier, L Rarova, P Korinkova, J Mikulik, M Budesinsky, T Beres, K Berka, Lu Q, Russinova E, M Strnad. (2016) Design, Synthesis and Biological Activities of New Brassinosteroid Analogues with a Phenyl Group in the Side Chain. Org Biomol Chem, 14 (37), 86918701.